Protein Name | PHD finger protein 1 |
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Organism | Homo sapiens |
Gene ID | 5252 |
Gene Symbol | PHF1 |
UniProt | O43189 (PHF1_HUMAN), A0A140VJR4 (A0A140VJR4_HUMAN), A0A1U9X8A3 (A0A1U9X8A3_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
413
Total Number of Articles : 364 |
Description |
PHD finger protein 1 |
Gene Summary |
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
synonyms |
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Properties | |