Protein Name PHD finger protein 1
Organism Homo sapiens
Gene ID 5252
Gene Symbol


UniProt O43189 (PHF1_HUMAN), A0A140VJR4 (A0A140VJR4_HUMAN), A0A1U9X8A3 (A0A1U9X8A3_HUMAN)
Relationships Total Number of functionally related compound(s) : 413
Total Number of Articles : 364

PHD finger protein 1

Gene Summary

This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

  • PHD finger protein 1
  • hPCl1
  • polycomb-like 1
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