Protein Name PIF1 5'-to-3' DNA helicase
Organism Homo sapiens
Gene ID 80119
Gene Symbol

PIF1

UniProt Q9H611 (PIF1_HUMAN)
Relationships Total Number of functionally related compound(s) : 84
Total Number of Articles : 69
Description

PIF1 5'-to-3' DNA helicase

Gene Summary

This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]

synonyms
  • ATP-dependent DNA helicase PIF1
  • DNA repair and recombination helicase PIF1
  • PIF1 5'-to-3' DNA helicase homolog
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Properties