Protein Name prostaglandin D2 synthase
Organism Homo sapiens
Gene ID 5730
Gene Symbol


UniProt P41222 (PTGDS_HUMAN), A0A024R8G3 (A0A024R8G3_HUMAN)
Relationships Total Number of functionally related compound(s) : 397
Total Number of Articles : 636

prostaglandin D2 synthase

Gene Summary

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

  • prostaglandin-H2 D-isomerase
  • PGD2 synthase
  • beta-trace protein
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