| Protein Name | erb-b2 receptor tyrosine kinase 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24337 |
| Gene Symbol | Erbb2 |
| UniProt | Q8K3F9 (Q8K3F9_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
72
Total Number of Articles : 89 |
Description |
erb-b2 receptor tyrosine kinase 2 |
| Gene Summary |
Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including ERBB2-ERBB4 signaling pathway; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and postsynaptic membrane. Biomarker of amblyopia; congestive heart failure; interstitial cystitis; median neuropathy; and myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jun 2025] |
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