| Protein Name | centromere protein A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1058 |
| Gene Symbol | CENPA |
| UniProt | P49450 (CENPA_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
52
Total Number of Articles : 67 |
Description |
centromere protein A |
| Gene Summary |
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] |
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