Protein Name TIMP metallopeptidase inhibitor 3
Organism Rattus norvegicus
Gene ID 25358
Gene Symbol

Timp3

UniProt Q4V8L0 (Q4V8L0_RAT)
Relationships Total Number of functionally related compound(s) : 60
Total Number of Articles : 49
Description

TIMP metallopeptidase inhibitor 3

Gene Summary

Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in several processes, including cellular response to peptide; mesenchymal cell differentiation involved in bone development; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix and extracellular space. Biomarker of sciatic neuropathy and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • metalloproteinase inhibitor 3
  • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
  • tissue inhibitor of metalloproteinases 3
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Properties