| Protein Name | persephin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5623 |
| Gene Symbol | PSPN |
| UniProt | O60542 (PSPN_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
19
Total Number of Articles : 10 |
Description |
persephin |
| Gene Summary |
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016] |
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