Protein Name tryptophan hydroxylase 1b
Organism Danio rerio
Gene ID 415103
Gene Symbol

tph1b

UniProt A2VCX5 (A2VCX5_DANRE)
Relationships Total Number of functionally related compound(s) : 6
Total Number of Articles : 7
Description

tryptophan hydroxylase 1b

Gene Summary

Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in axial mesoderm; axis; epiphysis; margin; and raphe nucleus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and heroin dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • tryptophan 5-hydroxylase 1b
  • tph1-2
  • tryptophan hydroxylase 1, like
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Properties