| Protein Name | SET domain, bifurcated 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 84505 |
| Gene Symbol | Setdb1 |
| UniProt | D3YYC3 (D3YYC3_MOUSE), G5E8N3 (G5E8N3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 36 |
Description |
SET domain, bifurcated 1 |
| Gene Summary |
Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |