Protein Name ATPase copper transporting beta
Organism Rattus norvegicus
Gene ID 24218
Gene Symbol

Atp7b

UniProt Q9QUG4 (Q9QUG4_RAT), A0A0G2JWJ5 (A0A0G2JWJ5_RAT)
Relationships Total Number of functionally related compound(s) : 24
Total Number of Articles : 49
Description

ATPase copper transporting beta

Gene Summary

Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • copper-transporting ATPase 2
  • ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)
  • PINA gene, promoter
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Properties