| Protein Name | synaptic Ras GTPase activating protein 1 homolog (rat) |
|---|---|
| Organism | Mus musculus |
| Gene ID | 240057 |
| Gene Symbol | Syngap1 |
| UniProt | F6SEU4 (SYGP1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 12 |
Description |
synaptic Ras GTPase activating protein 1 homolog (rat) |
| Gene Summary |
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016] |
| synonyms |
|
| Properties | |