| Protein Name | transcription termination factor 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7270 |
| Gene Symbol | TTF1 |
| UniProt | Q15361 (TTF1_HUMAN), A0A024R8C1 (A0A024R8C1_HUMAN), A0A087WY09 (A0A087WY09_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
61
Total Number of Articles : 58 |
Description |
transcription termination factor 1 |
| Gene Summary |
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
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