| Protein Name | nudix hydrolase 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 11164 |
| Gene Symbol | NUDT5 |
| UniProt | Q9UKK9 (NUDT5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
50
Total Number of Articles : 28 |
Description |
nudix hydrolase 5 |
| Gene Summary |
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013] |
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| Properties | |