| Protein Name | asporin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 54829 |
| Gene Symbol | ASPN |
| UniProt | Q9BXN1 (ASPN_HUMAN), Q6P528 (Q6P528_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
47
Total Number of Articles : 57 |
Description |
asporin |
| Gene Summary |
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014] |
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| Properties | |