Protein Name major histocompatibility complex, class I, B
Organism Homo sapiens
Gene ID 3106
Gene Symbol


UniProt P01889 (HLAB_HUMAN), E5FQ95 (E5FQ95_HUMAN)
Relationships Total Number of functionally related compound(s) : 377
Total Number of Articles : 1132

major histocompatibility complex, class I, B

Gene Summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

  • major histocompatibility complex, class I, B
  • HLA class I antigen HLA-B
  • HLA class I histocompatibility antigen, B alpha chain
Click to show/hide the synonyms