| Protein Name | lymphocyte-activation gene 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16768 |
| Gene Symbol | Lag3 |
| UniProt | Q61790 (LAG3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
21
Total Number of Articles : 18 |
Description |
lymphocyte-activation gene 3 |
| Gene Summary |
Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Acts upstream of or within negative regulation of interleukin-2 production and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |