Protein Name NBL1, DAN family BMP antagonist
Organism Homo sapiens
Gene ID 4681
Gene Symbol


UniProt P41271 (NBL1_HUMAN), A0A087WTY6 (A0A087WTY6_HUMAN)
Relationships Total Number of functionally related compound(s) : 1578
Total Number of Articles : 2287

NBL1, DAN family BMP antagonist

Gene Summary

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

  • neuroblastoma suppressor of tumorigenicity 1
  • DAN domain family member 1
  • differential screening-selected gene aberrant in neuroblastoma
Click to show/hide the synonyms