Protein Name twist family bHLH transcription factor 2
Organism Homo sapiens
Gene ID 117581
Gene Symbol

TWIST2

UniProt Q8WVJ9 (TWST2_HUMAN), A1MB48 (A1MB48_HUMAN)
Relationships Total Number of functionally related compound(s) : 38
Total Number of Articles : 33
Description

twist family bHLH transcription factor 2

Gene Summary

The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]

synonyms
  • twist-related protein 2
  • class A basic helix-loop-helix protein 39
  • dermis-expressed protein 1
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Properties