Protein Name ubiquitin C-terminal hydrolase L1
Organism Rattus norvegicus
Gene ID 29545
Gene Symbol

Uchl1

UniProt Q00981 (UCHL1_RAT)
Relationships Total Number of functionally related compound(s) : 48
Total Number of Articles : 50
Description

ubiquitin C-terminal hydrolase L1

Gene Summary

Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; cysteine-type peptidase activity; and ubiquitin protein ligase binding activity. Involved in sensory perception of pain and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • ubiquitin carboxyl-terminal hydrolase isozyme L1
  • PGP 9.5
  • PGP9.5
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Properties