Protein Name TNF superfamily member 13
Organism Homo sapiens
Gene ID 8741
Gene Symbol

TNFSF13

UniProt O75888 (TNF13_HUMAN), Q2QBA2 (Q2QBA2_HUMAN), B3KR02 (B3KR02_HUMAN)
Relationships Total Number of functionally related compound(s) : 42
Total Number of Articles : 40
Description

TNF superfamily member 13

Gene Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

synonyms
  • tumor necrosis factor ligand superfamily member 13
  • TNF- and APOL-related leukocyte expressed ligand 2
  • a proliferation-inducing ligand
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Properties