| Protein Name | selenoprotein S |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55829 |
| Gene Symbol | SELENOS |
| UniProt | Q9BQE4 (SELS_HUMAN), Q6GYA4 (Q6GYA4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
44
Total Number of Articles : 40 |
Description |
selenoprotein S |
| Gene Summary |
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017] |
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