| Protein Name | apoptotic peptidase activating factor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11783 |
| Gene Symbol | Apaf1 |
| UniProt | O88879 (APAF_MOUSE), G3XA09 (G3XA09_MOUSE), Q5DU30 (Q5DU30_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
52
Total Number of Articles : 53 |
Description |
apoptotic peptidase activating factor 1 |
| Gene Summary |
Enables cysteine-type endopeptidase activator activity involved in apoptotic process and identical protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including nervous system development; positive regulation of apoptotic signaling pathway; and regulation of apoptotic DNA fragmentation. Located in cytosol and nucleus. Is expressed in several structures, including autopod; brain; inner cell mass; inner ear; and neural retina. Used to study Noonan syndrome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |