Protein Name mitogen-activated protein kinase kinase kinase 14
Organism Homo sapiens
Gene ID 9020
Gene Symbol

MAP3K14

UniProt Q99558 (M3K14_HUMAN), Q68D39 (Q68D39_HUMAN)
Relationships Total Number of functionally related compound(s) : 101
Total Number of Articles : 105
Description

mitogen-activated protein kinase kinase kinase 14

Gene Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

synonyms
  • mitogen-activated protein kinase kinase kinase 14
  • NF-kappa-beta-inducing kinase
  • serine/threonine-protein kinase NIK
Click to show/hide the synonyms
Properties