| Protein Name | myosin heavy chain 11 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4629 |
| Gene Symbol | MYH11 |
| UniProt | P35749 (MYH11_HUMAN), A0A024QZJ4 (A0A024QZJ4_HUMAN), A0A024QZJ6 (A0A024QZJ6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
42
Total Number of Articles : 41 |
Description |
myosin heavy chain 11 |
| Gene Summary |
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022] |
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