Protein Name dopamine receptor D3
Organism Rattus norvegicus
Gene ID 29238
Gene Symbol

Drd3

UniProt P19020 (DRD3_RAT)
Relationships Total Number of functionally related compound(s) : 155
Total Number of Articles : 238
Description

dopamine receptor D3

Gene Summary

Enables D1 dopamine receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • D(3) dopamine receptor
  • dopaminergic receptor D3
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Properties