| Protein Name | dopamine receptor D3 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29238 |
| Gene Symbol | Drd3 |
| UniProt | P19020 (DRD3_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
155
Total Number of Articles : 238 |
Description |
dopamine receptor D3 |
| Gene Summary |
Enables D1 dopamine receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; cell projection; and endocytic vesicle. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of absence epilepsy and heroin dependence. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |