Protein Name reticulon 3
Organism Homo sapiens
Gene ID 10313
Gene Symbol

RTN3

UniProt O95197 (RTN3_HUMAN), A0A024R5C4 (A0A024R5C4_HUMAN)
Relationships Total Number of functionally related compound(s) : 303
Total Number of Articles : 317
Description

reticulon 3

Gene Summary

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

synonyms
  • reticulon-3
  • ASY interacting protein
  • NSP-like protein 2
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Properties