| Protein Name | ring finger protein 8 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9025 |
| Gene Symbol | RNF8 |
| UniProt | O76064 (RNF8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
33
Total Number of Articles : 45 |
Description |
ring finger protein 8 |
| Gene Summary |
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
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