Protein Name glucosaminyl (N-acetyl) transferase 2 (I blood group)
Organism Homo sapiens
Gene ID 2651
Gene Symbol

GCNT2

UniProt Q8N0V5 (GNT2A_HUMAN)
Relationships Total Number of functionally related compound(s) : 13
Total Number of Articles : 11
Description

glucosaminyl (N-acetyl) transferase 2 (I blood group)

Gene Summary

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

synonyms
  • N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
  • I beta-1,6-N-acetylglucosaminyltransferase
  • Ii blood group
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Properties