| Protein Name | Dorsal-related immunity factor |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 35045 |
| Gene Symbol | Dif |
| UniProt | P98149 (DIF_DROME), E1JHK2 (E1JHK2_DROME), E1JHK1 (E1JHK1_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
7
Total Number of Articles : 7 |
Description |
Dorsal-related immunity factor |
| Gene Summary |
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Toll signaling pathway; positive regulation of macromolecule biosynthetic process; and salivary gland histolysis. Located in cytosol and nucleus. Is expressed in adult heart; embryonic/larval fat body; embryonic/larval posterior spiracle; and embryonic/larval salivary gland. Used to study bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; carcinoma (multiple); ductal carcinoma in situ; immunodeficiency 53; and immunodeficiency 92. Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit) and RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jul 2025] |
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