Protein Name ALG12 alpha-1,6-mannosyltransferase
Organism Homo sapiens
Gene ID 79087
Gene Symbol

ALG12

UniProt Q9BV10 (ALG12_HUMAN), A0A024R4V6 (A0A024R4V6_HUMAN)
Relationships Total Number of functionally related compound(s) : 24
Total Number of Articles : 16
Description

ALG12 alpha-1,6-mannosyltransferase

Gene Summary

This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]

synonyms
  • dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
  • asparagine-linked glycosylation 12 homolog (S. cerevisiae, alpha-1,6-mannosyltransferase)
  • asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase)
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Properties