| Protein Name | glycophorin B (MNS blood group) |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2994 |
| Gene Symbol | GYPB |
| UniProt | P06028 (GLPB_HUMAN), B8Q175 (B8Q175_HUMAN), D6RBP2 (D6RBP2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
88
Total Number of Articles : 65 |
Description |
glycophorin B (MNS blood group) |
| Gene Summary |
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
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| Properties | |