| Protein Name | thioredoxin reductase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 26462 |
| Gene Symbol | Txnrd2 |
| UniProt | Q9JLT4 (TRXR2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
37
Total Number of Articles : 29 |
Description |
thioredoxin reductase 2 |
| Gene Summary |
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2017] |
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