| Protein Name | TNF receptor superfamily member 8 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 943 |
| Gene Symbol | TNFRSF8 |
| UniProt | P28908 (TNR8_HUMAN), A5D8T4 (A5D8T4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
232
Total Number of Articles : 310 |
Description |
TNF receptor superfamily member 8 |
| Gene Summary |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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