Protein Name TNF receptor superfamily member 8
Organism Homo sapiens
Gene ID 943
Gene Symbol


UniProt P28908 (TNR8_HUMAN), A5D8T4 (A5D8T4_HUMAN)
Relationships Total Number of functionally related compound(s) : 232
Total Number of Articles : 310

TNF receptor superfamily member 8

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

  • tumor necrosis factor receptor superfamily member 8
  • CD30L receptor
  • Ki-1 antigen
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