| Protein Name | splicing factor 3b subunit 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10992 |
| Gene Symbol | SF3B2 |
| UniProt | Q13435 (SF3B2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
16
Total Number of Articles : 12 |
Description |
splicing factor 3b subunit 2 |
| Gene Summary |
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008] |
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| Properties | |