Protein Name p21 (RAC1) activated kinase 6
Organism Homo sapiens
Gene ID 56924
Gene Symbol

PAK6

UniProt Q9NQU5 (PAK6_HUMAN), A0A024R9Q4 (A0A024R9Q4_HUMAN)
Relationships Total Number of functionally related compound(s) : 20
Total Number of Articles : 18
Description

p21 (RAC1) activated kinase 6

Gene Summary

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

synonyms
  • serine/threonine-protein kinase PAK 6
  • p21 protein (Cdc42/Rac)-activated kinase 6
  • p21(CDKN1A)-activated kinase 6
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Properties