| Protein Name | phosphatidylinositol-binding protein SCS2 |
|---|---|
| Organism | Saccharomyces cerevisiae S288C |
| Gene ID | 856856 |
| Gene Symbol | SCS2 |
| UniProt | P40075 (SCS2_YEAST) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 18 |
Description |
phosphatidylinositol-binding protein SCS2 |
| Gene Summary |
Enables FFAT motif binding activity and phosphatidylinositol binding activity. Involved in several processes, including endoplasmic reticulum organization; negative regulation of protein import into nucleus; and regulation of phosphatidylinositol dephosphorylation. Acts upstream of or within cellular response to starvation and reticulophagy. Located in several cellular components, including cellular bud tip; nuclear membrane; and nucleus-vacuole junction. Used to study amyotrophic lateral sclerosis type 8. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
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| Properties | |