| Protein Name | nucleotide-binding oligomerization domain containing 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 291912 |
| Gene Symbol | Nod2 |
| UniProt | D4A5W3 (D4A5W3_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 15 |
Description |
nucleotide-binding oligomerization domain containing 2 |
| Gene Summary |
Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and plasma membrane. Predicted to be extrinsic component of plasma membrane. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |