| Protein Name | transforming growth factor, beta receptor 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29591 |
| Gene Symbol | Tgfbr1 |
| UniProt | P80204 (TGFR1_RAT), Q5M9H3 (Q5M9H3_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
74
Total Number of Articles : 82 |
Description |
transforming growth factor, beta receptor 1 |
| Gene Summary |
Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including regulation of miRNA transcription; response to prostaglandin E; and transforming growth factor beta receptor signaling pathway. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); colorectal cancer; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |