Protein Name protein phosphatase 1, regulatory subunit 15A
Organism Mus musculus
Gene ID 17872
Gene Symbol

Ppp1r15a

UniProt P17564 (PR15A_MOUSE), B2RRL7 (B2RRL7_MOUSE)
Relationships Total Number of functionally related compound(s) : 38
Total Number of Articles : 36
Description

protein phosphatase 1, regulatory subunit 15A

Gene Summary

Enables protein phosphatase binding activity and protein phosphatase regulator activity. Involved in positive regulation of signal transduction by p53 class mediator; regulation of gene expression; and response to endoplasmic reticulum stress. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and hemolymphoid system gland. Used to study thalassemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • protein phosphatase 1 regulatory subunit 15A
  • growth arrest and DNA damage-inducible protein GADD34
  • growth arrest and DNA-damage-inducible 34
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Properties