Protein Name endoplasmic reticulum to nucleus signalling 2
Organism Mus musculus
Gene ID 26918
Gene Symbol

Ern2

UniProt Q9Z2E3 (ERN2_MOUSE), Q3UTN5 (Q3UTN5_MOUSE), Q32MS5 (Q32MS5_MOUSE)
Relationships Total Number of functionally related compound(s) : 71
Total Number of Articles : 70
Description

endoplasmic reticulum to nucleus signalling 2

Gene Summary

Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and unfolded protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and regulation of DNA-templated transcription. Located in endoplasmic reticulum quality control compartment. Part of IRE1-TRAF2-ASK1 complex. Is expressed in central nervous system and retina. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • serine/threonine-protein kinase/endoribonuclease IRE2
  • endoplasmic reticulum (ER) to nucleus signalling 2
  • endoplasmic reticulum-to-nucleus signaling 2
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Properties