CPRiL

Protein Name	ERCC excision repair 3, TFIIH core complex helicase subunit
Organism	Homo sapiens
Gene ID	2071
Gene Symbol	ERCC3
UniProt	P19447 (ERCC3_HUMAN), G3V1S1 (G3V1S1_HUMAN), B3KRG2 (B3KRG2_HUMAN), B3KTH1 (B3KTH1_HUMAN)
Relationships	Total Number of functionally related compound(s) : 36 Total Number of Articles : 52
Description	ERCC excision repair 3, TFIIH core complex helicase subunit
Gene Summary	This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
synonyms	general transcription and DNA repair factor IIH helicase subunit XPB BTF2 p89 DNA excision repair protein ERCC-3 DNA repair helicase DNA repair protein complementing XP-B cells TFIIH 89 kDa subunit TFIIH basal transcription factor complex 89 kDa subunit TFIIH basal transcription factor complex helicase XPB subunit TFIIH p89 TFIIH subunit XPB basic transcription factor 2 89 kDa subunit excision repair cross-complementation group 3 excision repair cross-complementing rodent repair deficiency, complementation group 3 xeroderma pigmentosum group B-complementing protein xeroderma pigmentosum, complementation group B BTF2 GTF2H RAD25 Ssl2 TFIIH TTD2 XPB Click to show/hide the synonyms
Properties