| Protein Name | granulin |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14824 |
| Gene Symbol | Grn |
| UniProt | P28798 (GRN_MOUSE), Q3U9N4 (Q3U9N4_MOUSE), Q544Y8 (Q544Y8_MOUSE), Q9D2V3 (Q9D2V3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
92
Total Number of Articles : 83 |
Description |
granulin |
| Gene Summary |
Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including glial cell activation; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and positive regulation of cell population proliferation. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including brain; early conceptus; gonad; placenta; and skin. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |