CPRiL

Protein Name	calcium voltage-gated channel subunit alpha1 A
Organism	Rattus norvegicus
Gene ID	25398
Gene Symbol	Cacna1a
UniProt	P54282 (CAC1A_RAT), O70368 (O70368_RAT)
Relationships	Total Number of functionally related compound(s) : 63 Total Number of Articles : 59
Description	calcium voltage-gated channel subunit alpha1 A
Gene Summary	Enables calmodulin binding activity and high voltage-gated calcium channel activity. Involved in calcium ion import; chemical synaptic transmission; and regulation of voltage-gated calcium channel activity. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in calyx of Held and presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in brain disease (multiple) and episodic ataxia type 2. Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Jun 2025]
synonyms	voltage-dependent P/Q-type calcium channel subunit alpha-1A BI RBA-I brain calcium channel 1 brain calcium channel I brain class A calcium channel alpha 1A calcium channel, L type, alpha-1 polypeptide calcium channel, voltage-dependent, P/Q type, alpha 1A subunit calcium channel, voltage-dependent, alpha 1A subunit voltage-gated calcium channel subunit alpha Cav2.1 BccA1 Cav2.1 rbA-1 Click to show/hide the synonyms
Properties