| Protein Name | sulfatase 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55959 |
| Gene Symbol | SULF2 |
| UniProt | Q8IWU5 (SULF2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
66
Total Number of Articles : 67 |
Description |
sulfatase 2 |
| Gene Summary |
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008] |
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