Protein Name EPH receptor B4
Organism Homo sapiens
Gene ID 2050
Gene Symbol

EPHB4

UniProt P54760 (EPHB4_HUMAN), Q96L35 (Q96L35_HUMAN), Q541P7 (Q541P7_HUMAN)
Relationships Total Number of functionally related compound(s) : 100
Total Number of Articles : 102
Description

EPH receptor B4

Gene Summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

synonyms
  • ephrin type-B receptor 4
  • ephrin receptor EphB4
  • hepatoma transmembrane kinase
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Properties