| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 23794 |
| Gene Symbol | Adamts5 |
| UniProt | Q9R001 (ATS5_MOUSE), Q8BGP4 (Q8BGP4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
62
Total Number of Articles : 57 |
Description |
ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Gene Summary |
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016] |
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