| Protein Name | regulator of G protein signaling 4 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5999 |
| Gene Symbol | RGS4 |
| UniProt | P49798 (RGS4_HUMAN), A0A024R909 (A0A024R909_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
109
Total Number of Articles : 98 |
Description |
regulator of G protein signaling 4 |
| Gene Summary |
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
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