| Protein Name | transforming growth factor, beta receptor II |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21813 |
| Gene Symbol | Tgfbr2 |
| UniProt | Q62312 (TGFR2_MOUSE), Q543C0 (Q543C0_MOUSE), Q3UG22 (Q3UG22_MOUSE), Q8BQS9 (Q8BQS9_MOUSE) |
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Total Number of functionally related compound(s) :
76
Total Number of Articles : 90 |
Description |
transforming growth factor, beta receptor II |
| Gene Summary |
Enables several functions, including kinase activator activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including circulatory system development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of tolerance induction; and respiratory system development. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; embryo mesenchyme; genitourinary system; and nervous system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Jun 2025] |
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