| Protein Name | 5-hydroxytryptamine (serotonin) receptor 2B |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15559 |
| Gene Symbol | Htr2b |
| UniProt | Q02152 (5HT2B_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
52
Total Number of Articles : 64 |
Description |
5-hydroxytryptamine (serotonin) receptor 2B |
| Gene Summary |
Enables G protein-coupled serotonin receptor activity; GTPase activator activity; and serotonin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; phospholipase C-activating serotonin receptor signaling pathway; and positive regulation of endothelial cell proliferation. Acts upstream of or within heart development. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; reproductive system; and sensory organ. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Jul 2025] |
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