| Protein Name | sestrin 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 27244 |
| Gene Symbol | SESN1 |
| UniProt | Q9Y6P5 (SESN1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
31
Total Number of Articles : 35 |
Description |
sestrin 1 |
| Gene Summary |
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
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